The use of mind-altering substances in mystical experience has been with us probably since mankind first discovered these substances. I have no experience with mind-altering substances other than alcohol so I will be using that as the primary example. What I have to say most likely applies to substances other than alcohol but that is for you to decide.
Moving through the various literature or communities that discuss metaphysical or mystical experiences you will probably come across those that feel that entheogens and mind-altering substances are tools for experiencing spiritual reality. You will probably also encounter those that feel one should never use these substances because they will hinder ones abilities and progress or they will simply trick the person into believing they are having a profound experience when it was really nothing but the effects of a psychoactive substance. There are more complexities such as the legality and availability of certain substances, the culture that comes along with them, and the possible risks to health but for the purposes of this post I'll focus on the question of whether using substances makes an experience less real than not using substances.
Again, I speak only from the perspective of using alcohol but alcohol is considered to be psychoactive so what I say should be relevant to those that use other substances. I find that using alcohol for mystical purposes simply makes it easier to enter certain states of mind. If I am drunk then I am drunk whether I am being mystical or just watching TV. There is a certain baseline to the experience of drinking alcohol. Alcohol typically affects memory and motor function and usually will not make you experience profound spiritual truths without a little effort on your part. This has been my experience at least.
What I am trying to convey is that simply being inebriated has a character of its own just as being sober has a character of its own. One can choose to perform mundane activities or mystical activities in either state and aside from the obvious effects on memory and motor function there will not be a lot of difference in the experience. I have found that alcohol makes it easier to access the states of mind required for mystical experience, probably because of alcohol's famous ability to lower inhibitions all around. Alcohol also allows a person to relax which is, in my opinion, a fundamental prerequisite for altered states of consciousness.
Broadening the example a little bit we could ask the question: Does a mind-altering substance cause you to have a mystical experience or does the substance allow you to have a mystical experience? I'm sure there are as many opinions as there are people that possess them. I think that if a person has experience with a substance outside of a mystical context then they will be able to tell when they are simply under the influence and when something a little more out of the ordinary is going on. Just as we notice a difference from everyday consciousness when drinking alcohol because we are sober most of the time we will begin to notice when something goes beyond the effects of a substance if we have enough experience with that substance to know how it normally affects us.
This is not to say you should run out and buy drugs or alcohol because they might help you into altered states of consciousness. I'm writing this only to give my perspective on the entheogen debate. One does not have to use mind-altering substances to have spiritual experiences. I have had profound experiences while absolutely sober and to date nothing I've experienced while intoxicated has compared to my sober experiences. I only observe that alcohol helps me reach a calmer, more receptive state faster. It does have its drawbacks in that being inebriated can be distracting to ritual or other relatively complex mystical contexts. There seems to be a "magic" amount that gives you all the benefits with few of the drawbacks and this is probably different for everyone.
There you have it, my views on the use of mind-altering substances in a mystical or spiritual context. I could go on about the symbolism of alcohol or whether using these substances will actually hurt your spiritual progress but those are perhaps topics for another time. I do feel that some people probably should not use mind-altering substances because of personality flaws that could make them more susceptible to addiction or other problems. Not everyone is capable of controlling themselves and even the best of us can still fall prey to substance abuse so before using mind-altering substances for any reason, mystical or recreational, one has to examine themselves closely.
Ultimately the decision of whether to use or not is up to the individual and they must take responsibility for their choices and their actions. I'll say again that you can have intense spiritual experiences whether sober or intoxicated. For some people the use of mind-altering substances may be something they wish to explore. For those that want nothing to do with it then more power to you. I'm a firm believer that there are several paths to any destination and that all roads eventually lead to the same place.
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